Taking NAD+ supplements may help you live longer and keep your body healthy, but knowing which supplement will work best can be challenging. To find this out, we compare the Best NAD+ Supplements.
There are some evident proofs that NAD+ supplements can delay the aging process.
I recommend you avoid getting your hopes up for anything that claims to be an eternal youth cure.
However, you might have high energy and focus levels.
You may also observe an improvement in your appearance.
People are genuinely interested in the possibility of NAD+ being a cornerstone in physical maintenance, and you don't have to look any further than the biohacking community to know this.
But with all the hype, it's hard to know which supplements — and how much of them — are safe and effective for you to take.
Look at our top five NAD+ supplements; they may be just what you need to live a longer, healthier life.
Many people have recently opted for nicotinamide adenine dinucleotide supplements to boost their body's natural supply of the compound (NAD).
Many people use NAD+ supplements for short-term benefits, such as increased energy levels, even though research suggests it can help the body repair DNA, improve immunity, and halt aging.
Consider your present health situation and your desired results before making any decisions. (Source)
To help you out, we've looked at what's currently on the market to offer a different selection in the hope that one of them may reach the sweet spot for you.
What Are NAD Supplements?
NAD represents nicotinamide adenine dinucleotide.
Without the plus sign, NAD is a catch-all word for a variety of chemicals, including NAD+, which adds a hydrogen atom to become NADH.
But what effect does any of it have on the body?
NAD is a coenzyme that is essential to the function of our mitochondria, also known as the cell's powerhouse.
Better cell performance and waste elimination result from efficient mitochondrial function.
The incredible thing about increasing mitochondrial efficiency is that it affects almost every aspect of your body.
That implies NAD can target various systems without requiring you to take a plethora of supplements.
NAD+ is a primary ingredient in some supplements, although its bioavailability is significantly lower than that of two of its precursors, NR and NMN.
Dr. David Sinclair is one of the biggest advocates for NAD+ use.
Using NAD+ precursors rather than NAD+ results in increased NAD+ in your body.
However, there is some need for clarification regarding which precursor is the safest and most effective.
Understanding how each precursor works enables us to comprehend better how vitamin B3 is transformed into NAD+ in the body.
Most of the NAD in your body comes from two things: tryptophan and vitamin B3.
Niacin and nicotinamide are the two most well-known forms of vitamin B3, although nicotinamide riboside (NR) is a more efficient converter of NAD+ in the body.
Yet, NR does not instantly transform into NAD+.
Before doing any actual work, it must enter your cells as nicotinamide mononucleotide (NMN).
NAD+ is produced from NMN.
A benefit of NMN is that it can eventually be converted into NAD+.
NR vs. NMN
What's the use of NR if NMN can convert to NAD+ more efficiently?
Research conducted until recently showed that exogenous NMN had to be converted to NR before entering human cells, and only then could it be converted back to NMN and, ultimately, NAD+.
Quite obviously, there are more efficient methods.
Recently, it has been discovered that NMN can enter cells without first being converted to NR by specialized amino acid and polyamine transporter.
The development of this transporter in the gut of older mice indicates an attempt to decline NAD levels by obtaining additional NMN from the diet.
It also suggests that the NAD+ generation by NMN may be more linked with the functioning and well-being of the microbiome.
This, however, necessitates a massive amount of additional study to verify.
In conclusion, NR and NMN can elevate endogenous NAD+ production in humans.
Depending on how much of each you can take will likely determine which option you go with.
The elderly may benefit more from NMN than NR if their bodies improve their ability to absorb NMN directly with time.
NMN is slightly better based on the studies I reviewed and my personal experience.
However, NR's effects may be more pronounced in some cases; again, this may be due to differences in unique qualities like genetics and age. (Source)
Benefits Of Using NAD Supplements
Many illnesses and diseases that affect the entire body can be treated with NAD+.
Dementia and Alzheimer's disease treatment are two effective treatments that can be done with NAD+.
As a result of its high energy output.
NAD has many potential applications:
- Optimize your athletic potential
- Cures chronic fatigue syndrome
- Reduce your cholesterol levels
- Depression Treatment
- Manage hypertension
- Slow down the aging process
- Protect against the adverse effects of the AIDS medicine zidovudine (AZT)
- Reverse alcoholic liver
When treating depression or PD, NAD can be injected intravenously or into the muscle.
You'll have better mental capacity and performance if your brain cells are healthier.
NAD supplements may also benefit your skin.
Related: Check out my Liomen Prime Skincare Review here
Best NAD+ Supplements
1. ProHealth Longevity Pure NAD+
Fight Aging, Boost Heart Health, and Strengthen Your Muscles
By sending NMN to specific spots on the Slc12a8 NMN transporter in the small intestine, ProHealth Longevity Pure NAD+ increases NMN absorption by more than 100 times.
NMN supplements have been shown to improve many aspects of health, such as cognitive performance, cardiovascular health, body composition, and gene expression.
They can also improve muscular and cardiovascular endurance and strength.
The chemical that comes before niacin, called nicotinamide adenine dinucleotide (NMN), has been shown to affect health and lifespan significantly.
Unlike competing NMN products, ProHealth Longevity Pure NAD+ is made with no chemical solvents and is bottled in the USA at an FDA-approved facility.
About The Brand
As a well-known health supplement brand, ProHealth Longevity Pure NAD+ offers a wide range of supplements that help you feel younger and live longer.
You can choose from a range of doses and delivery methods with their NMN product line.
There are a variety of forms of supplementation to choose from, including powders, capsules, tablets, and lozenges.
They are among the most expensive brands, but their high-dose costs are competitive.
Ingredients
Here’s a list of all the ingredients included in ProHealth Longevity’s NMN offerings:
- NMN Pro 300mg – costs $36.42 (capsule)
- NMN Pro 500mg – costs $58 (capsule)
- NMN Pro 1,000mg – costs $115 (capsule)
- NMN Pro Sustained Release 250 mg – cost $75.50 (Tablet)
- NMN Pro Pure 15-1,000g – costs $46.41 to $1,354 (sublingual powder)
- NMN Pro Lozenges 250mg – cost $37.29 (Lozenge)
ProHealth Longevity Pure NAD+ Pros And Cons
Pros
- There are a variety of dosing options
- Available in tablet, powder, and lozenge form
- Free return within 30 days
- When you spend over $75, shipping is on the house!
Cons
- All lozenges have the same strength
- There is no independent testing
2. NMN SL Sublingual Powder
The NMN SL sublingual powder has a pleasant flavor, dissolves fast under the tongue, and is competitively priced.
Its low cost is unrivaled, even when compared to buying NMN powder in bulk.
This NMN supplement is our top pick from Renue by Science because it is easy to take and gives satisfactory outcomes.
About The Brand
Renue by Science is a top choice because of its wide range of options in terms of products and delivery methods.
Products like capsules, tablets, powders, and sublingual drops containing NR and NMN are available for purchase from Renue by Science.
These products often include NR or NMN in a liposomal formulation, which protects the nutrients from stomach acid and facilitates their conversion to NAD+.
Anyone who wants to get the most out of their NAD+ can do so by storing the NAD+ their bodies already make so that it can be used for as long as possible.
The role of NAD+ preservers, which can be just as crucial as that of NAD+ boosters, is often overlooked. Together with boosters, they can increase NAD+ production and stability.
If you're on the fence about whether or not you need an NAD+ supplement or unsure how much you should take to boost your body's natural NAD+ synthesis, a blood test from Renue by Science will help you decide.
A finger prick at home will allow you to transmit your sample immediately to the lab.
About a week after that, you should start seeing effects.
Ingredients
- Ingredients added to improve bioavailability and flavor.
- Plus, for a total of 22 grams, 14 grams of pure NMN powder, 8 grams of mannitol, and 3 teaspoons of citrus burst flavor.
- Each scoop contains approximately 190 milligrams of NMN (scoop provided).
- Third-party certified for purity (above 99%) and safety.
- This product was manufactured in an FDA-approved facility.
- There are no artificial colors, flavors, or preservatives. Non-GMO /gluten-free/vegan-friendly.
Sublingual use of Nicotinamide mononucleotide powder is recommended (under the tongue).
Instead of being digested in the stomach, a portion of the NMN is absorbed directly into the bloodstream and is quickly available to cells throughout the body.
NMN SL Sublingual Powder Pros And Cons
Pros
- Third-party purity testing
- There are numerous ways to take it
- NAD-preserving products are also available
- Skincare line based on NAD
- Lots of research is available for home testing for cellular health
- Free shipping on domestic US orders
Cons
- The return policy is poor
- There is no money-back guarantee
Pricing
NMN SL Sublingual Powder costs $31.95 for 22gms
3. Cymbiotika NMN
Nicotinamide Adenine Dinucleotide (NAD) levels can be raised in the body by taking Nicotinamide Mononucleotide from Cymbiotika, which is made with extra polyphenols and antioxidants.
Regarding energy, metabolism, and healthy gene expression, NAD is vital.
It has been shown that increasing the amount of NMN in the body can improve NAD production and stop the age-related drop in NAD.
About The Brand
Cymbiotika is a well-known and reliable brand for NAD+ supplements.
The brand sells NAD+ products like capsules, tablets, powders, and sublingual drops containing NR and NMN.
Ingredients
- NMN (Nicotinamide mononucleotide)
- Apigenin contains 98%
- Green Tea Extract (20% L-Theanine)
- Resveratrol (98% Transresveratrol)
- Green Coffee Bean (10% Caffeine)
- Other Ingredients: Veggie Capsule (Hypromellose)
Cymbiotika NMN Pros And Cons
Pros
- It helps keep DNA in good condition
- Protects against oxidative damage and delays aging
- It helps maintain energy and metabolism within cells
Cons
- There is no independent testing.
Pricing
Cymbiotika NMN + Trans-Resveratrol – costs $69.30 (capsules for 30 days)
4. ForestLeaf Nicotinamide NAD+
If you suffer from allergies, ForestLeaf Nicotinamide NAD+ is your ideal remedy.
In fact, only a small percentage of NMN supplements contain ingredients that are popular allergens.
Still, Forest Leaf does everything it can to make sure its system doesn't add anything harmful.
Forest Leaf also has the best money-back guarantee and the best customer service in general.
There is little distinction between the Approved Science assurance and the standard one.
If you spend more than $50 at Forest Leaf, you won't have to pay for return shipping.
You'll have to fork over some cash for returns through Approved Science.
About The Brand
Forest Leaf's ForestLeaf Nicotinamide NAD+ comes in a low dose of 250 milligrams.
The capsule shape of the pills allows for good absorption if the capsule dissolves in the stomach.
It simply isn't effective compared to sublingual administrations or doses of 1,000 mg.
Forest Leaf's NMN retails at $39.95 per bottle.
With their subscription service, you may save $9.99, bringing the per-bottle pricing down to $29.96.
If you prefer to receive the shipments in bulk, you may customize the shipping frequency and amount for up to four months.
This is the only option to avoid the $6.95 shipping fee that Forest Leaf waives if you spend more than $50, aside from combining it with other supplements.
Ingredients
ForestLeaf Nicotinamide NAD+ Pros And Cons
Pros
- Nicotinamide Mononucleotide (NMN) stimulates cellular pathways that increase NAD+ levels in the body
- NAD+ is needed for effective cellular energy utilization
- As these levels decline, the aging process increases
- Aids in the repair of DNA in the body
- Calorie restriction has a protective effect against age-related weight gain
- NAD+ turns food and drink into energy by changing into the version of itself that carries hydrogen (NADH), which helps burn fat and protein
Cons
- Third-party testing is only for absorption
- A single bottle of NMN is adequate to avail free shipping option
Pricing
ForestLeaf Nicotinamide NAD+ – costs $29.96 (250 mg per bottle – 60 capsules per bottle)
5. Life Extension NAD+ Cell Regenerator
The enzyme NAD+ is needed for healthy energy production in cells, and NIAGEN® nicotinamide riboside makes more of it.
Resveratrol makes people live longer in many ways.
Quercetin improves the way the heart and immune system work, and fisetin makes senescent cells die off.
Since it has easy-to-get versions of all four of these nutrients, Life Extension NAD+ Cell Regenerator is a great way to get energy, vitality, and protection against cell aging.
The enzyme NAD+ is needed for cells to make the most energy, and NIAGEN® nicotinamide riboside increases the amount of this nutrient in cells.
Resveratrol is a plant molecule found in red grapes and Japanese knotweed.
It has been shown to make people healthier and live longer.
Some studies have shown that drinking red wine can have health benefits, and you've probably already heard about this.
Researchers have found that the grapes used to make red wine contain resveratrol, a polyphenol that helps with many ways to stay healthy and live longer.
However, the bioavailability of regular resveratrol is somewhat low.
We solved this problem by putting the antioxidants trans-resveratrol (from Japanese knotweed), quercetin, and fisetin in a way that kept the nutrients from breaking down.
A significant increase in bioavailability follows from this.
About The Brand
Life Extension says that their supplements are guaranteed to be 100% pure and 100% effective.
In most cases, a responsible third party will verify this high standard, although this is sometimes the case.
Because they are so careful about quality, they have fewer options and slightly higher prices.
Ingredients
- Resveratrol Elite™ proprietary blend – 55mg
- NIAGEN® nicotinamide riboside Chloride – 300mg
- Bio-Quercetin phytosome – 14.7mg
- Bio-Fisetin proprietary blend – 2.22mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, and stearic acid.
Life Extension NAD+ Cell Regenerator Pros And Cons
Pros
- The quick delivery procedure increases the bioavailability of fisetin by 25 times, resveratrol by 10 times, and quercetin by 50 times
- Fights fatigue by encouraging youthful cellular energy production
- Encourages heart, mind, and cell health, contributing to overall longevity
- Contains quercetin and fisetin for extra health benefits
Cons
- The return policy is poor
- There is no money-back guarantee
Pricing
Life Extension NAD+ Cell Regenerator costs $40.50 (30 capsules)
Best NAD Supplements: Closing Thoughts
NAD+ supplements seem well-tolerated and safe.
They may have mild side effects, though: NR and NMN can upset your stomach, while NR can cause mild flushing.
These side effects, however, are rare and often mild.
Unfortunately, there has yet to be thorough research on NR or NMN's safety over the long term.
Our knowledge of NAD+ is extremely limited at present.
While its proponents in the supplement market tout it as a magical youth restorer, cancer researchers have found that patients with low NAD+ levels successfully stop tumor growth.
NAD+ may delay the onset of some age-related illnesses and promote cancer development. I advise you to be careful when taking NAD+ supplements. If you or a family member has a history of cancer, you should discuss taking a lower dose with your doctor before starting NAD+ supplementation.