I have always received advice that healthy eating habits and regular exercise play a key part in living a long and healthy life. Check out my round-up of the best spermidine supplements I could find.
Yet, aging is inevitable, and I have even seen those who followed their fitness rituals religiously age with various complications and health and aesthetic issues.
Fueling my curiosity, this lead me to explore different longevity supplements and wonder products that claim to slow down aging.
For years, I’ve been trying and dumping different anti-aging products and supplements, but then I came across spermidine and found many people hailing this naturally-occurring polyamine.
So, I kept digging and learned that it carries anti-aging properties and various health benefits as well.
Knowing its natural occurrence and health benefits, I started looking into various spermidine supplements that are often marketed for their anti-aging qualities.
Having tried a few of them already, and with all my research into spermidine, its benefits, and supplementation, I have compiled a list of the 5 best spermidine supplements that show proven results and can effectively increase your lifespan with a healthy, lively life ahead.
Before I share my reviews, however, here’s a quick look into some FAQs to help you understand what spermidine is and how it can help you live longer and healthy.
What Is Spermidine?
Spermidine — a natural polyamine — is a compound that stimulates autophagy.
This polyamine plays a critical part in cellular metabolism, but its levels in the body decline as we grow older, causing us to age faster.
Spermidine supplementation can help increase lifespan and improve health across species.
How does spermidine help slow down aging and extend lifespan?
It has the ability to stimulate autophagy, the body’s natural process of breaking down and reusing old cellular parts for cell renewal and allowing cells to work more efficiently.
As the cells become stressed and get deprived of nutrients, the natural cleaning-out process kicks in.
With increased autophagy, the cells are well-kept and perform optimally, hence extending their lifespan.
Furthermore, research shows that spermidine is capable of adjusting epigenetic expression.
It prevents gene suppression and turns back the clock on gene expression to slow down aging or even reverse it in some cases. (Source)
Does spermidine occur naturally?
Multiple foods have naturally occurring spermidine.
Wheat germ, mushrooms, natto, soybeans, cauliflower, and broccoli sprouts are some of the food sources with the highest amounts of natural spermidine.
Besides foods, human sperms also have high amounts of spermidine.
Does Spermidine have any side effects?
There are no known side effects of spermidine to date.
Is it safe to supplement on spermidine?
Spermidine occurs naturally in the human body, and all the trials show that spermidine supplementation is safe and has no side effects.
Let’s now look into spermidine supplements and explore my top picks on this best supplements list.
Spermidine Supplements 101
Most people dream of living a healthy, long, and fulfilling life.
However, only a few of them realize this dream.
More often, our genes and various environmental factors dictate our health and the longevity of our lives.
Fortunately, today we have research-backed supplements available to lengthen our lives and improve life quality.
As human cells age and even billions of them die daily, the natural aging process may slow down the growth of new cells, leading to the failure of significant organs.
That’s exactly how the natural concentrations of spermidine in the body tend to decline with age.
Therefore, supplementing on spermidine can help avail various health and anti-aging benefits.
Spermidine supplements promote natural and controlled cell regeneration and can help you stay in shape.
Best Spermidine Supplements
As I said earlier, multiple cell renewal and anti-aging supplements are available today.
However, they are not made equal, and experimenting with various options on the market may result in serious health issues.
But you can always count on my research and choose any of the best spermidine supplements listed below.
- Renue By Science LIPO Spermidine
- Oxford Healthspan Primeadine
- Longevity Labs + Spermidine Life Extra+
- Do Not Age Spermidine
- Double Wood Spermidine
I have compiled this list based on my personal experience with some of these products, the brand reputation, overall product quality, user reviews, and cost/value variables.
Let’s find out more in detail about these best spermidine supplements.
1. Renue By Science LIPO Spermidine
Renue By Science is a reputed brand known for its quality longevity supplements and offering a wide range of products.
This LIPO Spermidine supplement is one of their top products, developed in an FDA-approved facility, with a high purity level and proven anti-aging results.
Because spermidine doesn’t have great bioavailability, LIPO Spermidine relies on a sustained-released liposomal delivery mechanism to ensure better absorption and efficacy.
Even though it’s a cutting-edge supplement, I liked that it’s relatively more affordable than other products on the market, offering a greater value without compromising the product quality.
It gives you 4mg of spermidine per serving and makes a perfect choice if you’re looking for a powerful, extended-release spermidine supplement at an affordable price.
About The Brand
Previously named Alive By Science, Renue By Science is regarded as one of the industry leaders in the longevity supplements market.
Founded in Las Vegas almost a couple of decades back as an entrepreneurial venture that aimed at selling health products and supplements, the brand has come a long way forward to become the industry leader in bioavailable longevity supplements today.
They do a lot of experimentation and have achieved great results in making NAD+ and NMN products more bioavailable.
They are highly rated by their ever-increasing customer base and continue to work with the clear objectives of taking science forward, setting new quality assurance standards, and making their supplements more affordable and valuable.
Ingredients
- Wheat-germ extract
- Sunflower Lecithin
- D-Ribose
- Rice Flour
- Plant Cellulose Capsule
Renue By Science LIPO Spermidine Pros And Cons
Pros
- Helps increase NAD+ levels and reduce systemic inflammation
- Offers an adequate dose of 4mg of Spermidine in a single capsule
- Uses liposomal encapsulation technology to avoid degradation of ingredients in the stomach
- Better half-life and bioavailability than other supplements
Cons
- None reported to date
Pricing
- $59.95 for a one-time purchase
- 56.95 with subscribe and save (5% savings)
2. Oxford Healthspan Primeadine
Another high-quality product from a reputed brand, Primeadine gives you 1mg of spermidine in each serving.
However, what makes it one of the best spermidine supplements in my opinion, is that its formula includes resistant starch and prebiotic fiber to help the gut bacteria that produce spermidine to make spermidine naturally.
So, it increases the levels of spermidine in your body through supplementation and promotes natural spermidine production.
Another good thing about this product is that the spermidine it uses is obtained from highly-concentrated Japanese wheat germ.
The raw materials undergo rigorous testing and must meet the strictest quality standards the Japan Health Food and Nutrition Food Association set forth.
Oxford Healthspan’s Primeadine is the product for you if you intend to stimulate the natural spermidine production in the body besides receiving the daily dose from supplementation.
About The Brand
Leslie Kenny founded Oxford Healthspan after working with some top Oxford scientists to identify anti-aging compounds with strong profiles for clinical safety.
She wanted to make them available as nutritional supplements in the market.
Spermidine was among her first few discoveries that were made commercially available as a supplement.
Today, the brand promises to bring modern science and eastern wisdom together to introduce high-quality, science-backed, and effective botanical compounds in the market.
They research supplements and products that help the body reclaim its natural ability to repair and renew itself, promoting increased healthspan and vigorous longevity.
Ingredients
- Wheat-germ extract
- Maltodextrin FOS prebiotic fiber
- Hypromellose plant cellulose capsule
Oxford Healthspan Primeadine Pros And Cons
Pros
- Only product to stimulate the natural spermidine-producing bacteria in the body
- Unique formula that skips on unnecessary fillers and synthetic ingredients
- Carries aesthetic-enhancing characteristics like fuller hair, glowing skin, improved eyelashes, and reduced wrinkles
- Uses defatted and rigorously tested wheat-germ extract to avoid oxidation
Cons
- Not good for people with wheat allergy, Celiac disease, and SIBO
Pricing
- $90 for a one-time purchase
- 76.50 with subscribe and save (15% savings)
3. Longevity Labs + Spermidine Life Extra+
Regarding overall product quality, I can bet no other supplement can beat the Spermidine Life Extra+ from Longevity Labs +.
It gives you a little extra of the award-winning Spermidine Life, and you get double the amount of natural spermidine with each dose.
It’s a non-GMO, vegan-friendly wheat-germ extract that is free of any contaminants.
The high-quality spermidine in this product is attributed to its natural manufacturing process that doesn’t use any synthetics and combines spermidine with different other polyamines and micronutrients.
The product is intended for long-term use, and according to the manufacturer’s recommendation, you should use it for no less than 3 months to see the desired results.
Remember that it is a bit expensive though.
About The Brand
Longevity Labs + was founded in 2016 when DI Herbert Pock and Dr. Gerald Sitte started working on a special extraction method with researchers at the University of Graz.
In 2018, Dr. Hannes Androsch joined them as an investor, and the company started gaining attention quickly, even outside of the University of Graz.
The company is built on the foundation of translating scientific research into natural remedies for everyday life challenges.
In 2019, they translated their extensive research and testing into their first product, spermidineLife Original 365+.
This spermidine supplement was an instant success in Austria and paved the way for its expansion to the USA.
Today, Longevity Labs is a renowned name with a range of products and spermidine supplements transforming lives every day.
Ingredients
- CelVio wheat-germ extract
- Zinc
- Thiamine
- Hypromellose plant cellulose capsule
- Acetylated Starch
- Calcium Carbonate
- Magnesium Stearate
- Glycerol
Longevity Labs + Spermidine Life Extra+ Pros And Cons
Pros
- Double strength with 30% extra polyamines
- Tailor-made for vegetarians and vegans
- Uses award-winning wheat-germ extract for natural spermidine
- No artificial flavors or colors, nuts, caffeine, and lactose in the formula
- 100% GMO-free
Cons
- It contains gluten and wheat
- Not a recommended product for children and breastfeeding or pregnant women
Pricing
- 99$ for a one-time purchase
- 89$ with subscribe and save (10% savings)
SHOP THE SPERMIDINE LIFE EXTRA+
4. Do Not Age Spermidine
This spermidine supplement comes from a reputed UK-based vendor — Do Not Age — popular for their range of sirtuin-activating supplements.
The company is known for manufacturing high-quality supplements while still keeping them in an affordable price range.
The product uses 400mg of wheat-germ extract to get 4mg of Spermidine, something not common with other products.
That’s almost four times greater potency in a single capsule than many other competing products.
In addition, you get 1mg of Zinc Picolinate as well.
Even better, the spermidine used by Do Not Age is produced to ISO9001 and GMP standards.
You also have the company’s guarantee that you’ll receive the best quality product without oxidation and degradation of the supplement.
I liked their guaranteed potency policy and the fact that they ship globally.
About The Brand
Do Not Age is a reputed brand that aims to extend a healthy lifespan for the maximum number of people.
Their products are based on the latest research from the top longevity researchers and are priced at the lowest possible.
Headquartered in the UK, the brand has already built a community of over 100,000 people worldwide who share a single goal: to lengthen their healthy lifespan.
With an award-winning longevity scientist leading their board of advisors, they capitalize on the latest research breakthroughs and continue to improve their products to ensure they make a difference in the lives of people who trust them.
Ingredients
- Wheat-gram extract
- Zinc
- Cellulose
Do Not Age Spermidine Pros And Cons
Pros
- A strong product with 4x greater potency in a single capsule
- Uses high-quality spermidine produced to meet ISO9001 and GMP standards
- Ensures delivery of pure, maximum-quality spermidine without degradation
- Ships around the globe
Cons
- None reported to date
Pricing
- 60 capsules for $49
- 366 capsules for $290
SHOP THE DO NOT AGE SPERMIDINE
5. Double Wood Spermidine
I have always wanted to find the best spermidine supplements for those on a budget, and Double Wood Spermidine is certainly the one.
With this supplement, you get the highest spermidine dose for the lowest upfront cost.
Another thing I like about this supplement is that they display each batch’s testing results on its website to ensure transparency and build trust.
It is also marketed as a gluten-free and non-GMO supplement.
Despite all these great things, however, there are still a few questions about its bioavailability.
Furthermore, the testing is done for heavy metal content and the weight of the product.
There’s very little we know about the purity of spermidine in this supplement.
Nevertheless, it’s a good pick for those on a budget.
About The Brand
Founded back in 2013 by twin brothers Evan and Reese Wood, Double Wood Supplements was established with the single goal of introducing Dihydromyricetin – the revolutionary supplement for hangover prevention – in the US market.
Since then, they continued to expand their product line, and today Double Wood offers a range of anti-aging, brain health, immune support, and other niche supplements.
Over the years, they have earned a name as a trusted provider of some of the best high-quality supplements with high efficacy and proven results.
Ingredients
- Putrescine
- Rice Flour
- Plant Cellulose Capsule
Double Wood Spermidine Pros And Cons
Pros
- With 10mg of spermidine per serving, it’s the strongest supplement on my list
- Offers great value for money, giving you the highest dose of spermidine at the least expensive price upfront
- Global shipping makes it easily accessible anywhere in the world
Cons
- There are concerns around the bioavailability of spermidine in this product
- Very little research is available to support the effectiveness of Putrescine-derived spermidine
Pricing
- $49.95 for a one-time purchase
- $44.96 with subscribe to save (10% savings)
SHOP THE DOUBLE WOOD SPERMIDINE
Spermidine Capsules
Most spermidine supplements are available as spermidine capsules, and they have different dosages per serving.
You must read the label and safety instructions to make sure you are not overdosing yourself.
Generally, spermidine capsules are made using plant cellulose and are safe for consumption.
Spermidine Powder
While spermidine capsules are the generally adopted way of taking spermidine supplements, some popular brands have also engineered spermidine powder.
Based on their research, they claim it to be more effective.
However, more evidence is needed to compare the efficacy of spermidine capsules and spermidine powder.
Spermidine Dosage
Increased spermidine intake is often linked to increased survival rates and lower mortality in humans.
However, the spermidine dosage varies in different spermidine supplements.
Research shows that it is safe to consume 1-7mg of spermidine per day for humans.
Most studies recommend 1-2mg of daily spermidine intake, while a few suggest 7mg+ of spermidine as recommended daily intake.
Best Spermidine Supplements: Closing Thoughts
Spermidine is a naturally occurring polyamine with proven anti-aging and health benefits.
As natural levels of spermidine found in the body decline with age, taking spermidine supplements can help promote longevity and a healthy lifespan. (Source)
Spermidine supplements are still a budding market, and fewer reliable products exist.
You can choose the best spermidine supplements from my list above to give yourself a daily shot of rejuvenation.
I have carefully compiled this list and shortlisted the best spermidine supplements based on my personal experience with some of these products, the brand reputation, overall product quality, user reviews, and cost/value variables. Pick your spermidine supplement and start getting your shot of longevity today!
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This is wonderful, thank you! I recently switched fro a wheat derived spermidine (one on your list) to an algae based one (PlantPills). Wondering if you have researched the difference in benefits between the two?