Neo40 Review: Benefits, Drawbacks, And Comparison

Made by the simple-yet-scientific brand humann, Neo40 combines clinical science with a hefty dose of marketing hype.

But does this product live up to the hype? And what do customers say about it?

Stay tuned, because in this review we’ll be answering these questions and many more.

The Many Benefits of Beets

In today’s nutraceutical world, the term superfood gets thrown around too much.

That being said, beets are a true superfood. They’re one of the few foods that directly, tangibly improves your body’s ability to produce nitric oxide. And that’s just the start. Beets and beetroot powder possess numerous other health benefits, too.

We’ve covered the benefits of nitric oxide supplements before, and we’ve also dove deep into some of the industry's very best reds powders.

But in this review, we’ll be going over a slightly different type of beet-derived product.

It’s not quite a reds powder — it’s a pared-down, clinically-backed NO2-boosting blend!

Here are the details.

The Brand Behind Neo40

We’re pretty familiar with the brand that makes Neo40, humann, having reviewed their Superbeets formula in the past.

According to Superbeets CEO Joel Kocher, the brand’s mission is simple: “to change lives”.

However, the way they go about doing that is decidedly more complex. All humann’s products are designed to boost nitric oxide (NO) levels. The brand states the following on their website’s Our Story page.

Humann does indeed have a stellar reputation.

Over its 10+ years of operation, it claims to have gained the support of 1,400+ medical professionals, 120+ sports teams, and more!

HumanN Neo40’s Ingredients List

Neo40 contains three primary ingredients:

• A Beetroot Powder + Hawthorn Berry Extract that’s designed specifically to boost NO production
• L-Citrulline, a rare amino acid that also supports NO production, particularly during the aging process
• Sodium Nitrite, a ‘storage form’ of nitric oxide that is readily used by the body

In addition to 420mg of this Patented Nitric Oxide Formula, Neo40 also contains:

• 100mg of vitamin C (167% of your RDV)
• 50mcg of vitamin B12 (833% of your RDV)
• and several other ingredients

These less active ingredients include mannitol, modified cellulose, xylitol, natural flavors, magnesium vegetable stearate, silica, and stevia.

Here are the HumanN Neo40 supplement facts:

How to Take Neo40

Taking Neo40 is simple: place a tab on your tongue and allow it to dissolve slowly. DO NOT swallow the tab whole or place it under your tongue.

Humann says you can take two tabs daily during the 30-45-day “restoration loading phase.”

They caution not to take more than two, however.

The brand also recommends monitoring your NO levels with Nitric Oxide Indicator Strips™.

Neo40’s Top Health Benefits

Neo40 is specifically designed to support blood pressure and heart health daily.

Neo40 is a self-proclaimed “breakthrough” in blood pressure and heart health support because of the speed with which it boosts nitric oxide.

Neo40: Backed by Medical Professionals?

Normally the claims listed above would be a little too strong for my taste.

In this case, however, Neo40’s patented formula is backed by the University of Texas Health Science Center’s Nitric Oxide Discovery Program.

As we mentioned above, Neo40 is backed by many medical experts.

“I am strongly convinced by the science”, attests Dr. Ernst R. Schwarz, MD, PhD, FESC, FACC, FSCAI, who helped humann conduct its randomized, double-blind, placebo-controlled clinical trials.

A 12mmHg reduction in systolic blood pressure and 6mmHg reduction in diastolic pressure completely surprised me. We usually don’t see results this good. Neo40 is a very compelling product […].

Other MDs echo Schwarz’s statements:

Objectively, I believe [Neo40] has been a major asset in supporting blood pressure & arterial health,” says Mark H. Raterink, MD, ABIHM. “Neo40 is one of the most significant products to come onto the market.

HumanN Neo40: Is It Better Than L-arginine?

Neo40 also claims its product works better than L-arginine when it comes to boosting NO — and this claim is backed by science.

As humann explains:

• An enzyme called eNOS (Endothelial Nitric Oxide Synthase) is needed to convert L-arginine into nitric oxide. This enzyme’s production can be a serious rate-limiting factor.
• Neo40, on the other hand, supports both nitric oxide production and eNOS function, allowing it to boost NO almost regardless of a person’s age or health status.

Does Neo40 Have Positive Customer Reviews?

It does indeed.

In addition to being backed by medical professionals, Neo40 seems to have won the support of many satisfied customers.

Humann’s website currently has over 1,000 reviews averaging 4.6 stars each. On Amazon, you’ll see over 4,000 reviews averaging 4.3 stars each.

One customer says Neo40 gets to work fast:

Excellent product. Within a week of using this product I started feeling 100 times better. Highly recommend it!!!

Another customer experiences incredible results but is at least as upset with Neo40’s ever-increasing price:

This is a fantastic product for bringing blood supply into my spine which was causing severe neuropathy and the product was recommended by my fabulous and incredibly smart chiropractor. However, I gave the low rating because since I've started taking this three months ago, the price has more than doubled; in addition, each time I reorder, the price has jumped significantly!!! Price gauging is unacceptable […].

And here’s one more telling review:

I have been taking this for 1 week. It delivered results immediately. Lowered blood pressure, increased blood flow to my semi-numb right foot, if I took it before exercise it gave me extra wings. So far fantastic. I have tried many supplements, you know, as many of you, 50 and above, looking to feel your best […]this one feels like a gold mine.

Noticing a trend here? Most customers report that Neo40 works well — and fast — to improve circulation, reduce neuropathy, and boost athletic performance.

While some customers aren’t too happy about Neo40’s price, this seems to be its only oft-repeated downside.

Does Neo40 Have Side Effects?

Yes, Neo40’s ultra-high B12 content seems to cause side effects in some users.

One customer review says:

I started taking this to help high blood pressure and circulation, I’ve been taking it just a few weeks, and during that time I was having headaches, itchy skin, dizziness, very nauseous, then vomiting. I thought I had caught a bug.

Another customer says:

Well, I just saw it had 50 mcg in it per tablet!!! Yes….50! The normal adult is 2.6 mcg a day! The side effects of too much B12 are all my symptoms. I stopped taking it 3 days ago, and all the symptoms were gone.

While this customer’s review seems dramatic, its message is nonetheless relevant for the small subset of people that may be sensitive to B12.

Neo40 Pricing

Each pack of Neo40 costs $39.95 for a one-time purchase. That comes out to $1.33 per day/per tablet.

Subscribing gives you access to a 10% discount, bringing the price down to $35.95 per month, or $1.20 per day/per tablet.

Noe40 also offers customers a risk-free, no questions asked 90-day guarantee.

The guarantee offers a full refund, minus shipping and handling costs.

Where to Buy Neo40

You can buy Neo40 on humann’s website here or on Amazon here.

HumanN Neo40: My Verdict

All in all, I think Neo40 is a great product.

Medical professionals back it, clinically studied, and relatively affordable.

But it could still be better.

Neo40 features a few too many proprietary blends than I’d like to see, meaning we don’t know exactly how much beetroot powder or L-citrulline is in it.

Until better (i.e, more transparent) options become available, though, Neo40 remains one of the market’s best nitric-oxide-boosting supplements.

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